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Differentiation Syndrome (DS) A dangerous inflammatory reaction that happens when AML treatments (ATRA, IDH inhibitors, menin inhibitors) suddenly force leukemia cells to mature too fast → releasing cytokines → causing capillary leak and organ inflammation. Presentation (Think: fever lungs fluid): • Fever • Shortness of breath / low oxygen • Pulmonary infiltrates (looks like pneumonia) • Fluid overload (weight gain, edema) • Low BP • Pleural/pericardial effusions • Kidney dysfunction Often confu
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